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Much like AKB-48, 5F-AKB-48 is structurally similar to JWH 018 and STS-135. 5F-AKB-48 differs structurally from AKB-48 by having the fluorine molecule at the terminal carbon of the pentyl chain. While the physical differences of this uniqueness are until now unknown, quinolones with adamantyl-carboxamide moieties display a high affinity for the peripheral CB2 receptor but a greatly reduced affinity for the central CB1 receptor.